CALL FOR PAPERS Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle
نویسندگان
چکیده
Mac B. Robinson, Deepak A. Deshpande, Jeffery Chou, Wei Cui, Shelly Smith, Carl Langefeld, Annette T. Hastie, Eugene R. Bleecker, and Gregory A. Hawkins Wake Forest School of Medicine, Center for Genomics and Personalized Medicine Research, Winston-Salem, North Carolina; Wake Forest School of Medicine, Department of Neurobiology and Anatomy, Winston-Salem, North Carolina; Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania; and Wake Forest School of Medicine, Center for Public Health Genomics, Winston-Salem, North Carolina
منابع مشابه
IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle.
Genetic data suggest that IL-6 trans-signaling may have a pathogenic role in the lung; however, the effects of IL-6 trans-signaling on lung effector cells have not been investigated. In this study, human airway smooth muscle (HASM) cells were treated with IL-6 (classical) or IL-6+sIL6R (trans-signaling) for 24 h and gene expression was measured by RNAseq. Intracellular signaling and transcripti...
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متن کاملIL6 Trans-signaling Increases Expression of Airways Disease Genes in Airway Smooth
23 Genetic data suggests that IL6 trans-signaling may have a pathogenic role in the lung; however, 24 the effects of IL6 trans-signaling on lung effector cells have not been investigated. In this study, 25 human airway smooth muscle (HASM) cells were treated with IL6 (classical) or IL6+sIL6R 26 (trans-signaling) for 24 h and gene expression measured by RNAseq. Intracellular signaling and 27 tra...
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